Skip to Main Content




Medulloblastoma is a malignant (cancerous) brain tumor that arises from the cerebellum, the part of the brain that controls balance, coordination and other complex functions. Most patients have symptoms of headache and vomiting, and can also have problems with balance and vision when they are diagnosed.

About 15 to 20 percent of all childhood brain tumors are medulloblastoma. It is diagnosed most commonly in children and adolescents. For most patients, the cause of medulloblastoma is unknown. However, there are a few rare, genetic syndromes that may increase a person's chance of developing medulloblastoma.

Medulloblastoma is a member of a larger group of tumors called primitive neuroectodermal tumors, or PNETs. PNETs typically look similar when observed under a microscope, but additional microscopic, biologic and clinical features help doctors distinguish the different types of PNET. Other PNETs that can occur in the brain include atypical teratoid/rhabdoid tumor (ATRT), pineoblastoma and supratentorial PNET. All PNETs, including medulloblastoma, have the ability to spread throughout the entire central nervous system.

While many patients can be cured, some forms of the disease are resistant to all treatments, at which point the disease becomes life-threatening. In addition, while conventional treatments can be effective for many patients, survivors are at risk for developing long-term side effects. These include possible learning problems, hearing problems, hormone and growth problems, fertility problems, and secondary cancers that can develop later in life.

Signs & symptoms

Because of their location, symptoms caused by the growth of medulloblastomas usually result from blockage of cerebrospinal fluid (CSF) flow, or from direct pressure on the brain and cranial nerves. The build-up of CSF in the brain is called hydrocephalus, and causes the common pattern of symptoms such as headaches, nausea, vomiting and difficulty walking. Direct pressure on cranial nerves adjacent to the tumor can also cause double vision and difficulty speaking or swallowing.


When patients develop persistent headaches with vomiting, or symptoms caused by cranial nerve dysfunction, an imaging study is usually obtained. Although some patients will start with a CT scan of the head, an MRI is usually required to provide details of the tumor's location and its relationship to normal brain structures. Usually, additional images of the spine are also obtained to determine if the tumor has spread to the spinal cord.

Although there are several different kinds of tumors that can arise in the cerebellum, it is usually possible to narrow the diagnosis with advanced MRI scans.


The most effective treatment for medulloblastoma is a combination of therapies that include surgery, radiation treatment and chemotherapy. Complete surgical removal of the tumor is important and is usually the first step in treatment. This is usually followed by radiation treatment to the entire brain and spine in older patients, followed by several months of chemotherapy.

Standard treatment for very young children — often defined as children less than 3 years old — includes surgical removal and chemotherapy. The use of radiation in this young age group is controversial, but some doctors are increasingly using radiation restricted to the area of the tumor. Because these young patients cannot tolerate whole brain and spine radiation, increasingly intensive doses of chemotherapy are being tested, including high-dose chemotherapy with autologous stem cell rescue, a form of bone marrow transplant.

With aggressive treatment, many medulloblastoma patients can be cured of the cancer. For patients 3 years or older, with "average risk" disease (defined as compete removal of the tumor and no signs of tumor spread to other parts of the central nervous system and body), who are treated with a combination of complete surgical removal of the tumor, radiation and chemotherapy, more than 80 percent can be cured.

Patients with "high risk" disease (the tumor has spread or cannot be completely removed with surgery) can still be cured, but the cure rates are lower. Treatment for younger patients, who are more prone to complications from extensive radiation treatment, is evolving. The goal is to identify effective strategies that will hopefully spare the patient the long-term complications of extensive radiation to the brain.

UCSF Benioff Children's Hospitals medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your child's doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your child's provider.

Where to get care (3)


Brain Tumor Program

Brain Tumor Program

San Francisco / Oakland


Neurosurgery Program

Neurosurgery Program

San Francisco / Oakland / Los Gatos / Greenbrae / Modesto / Sacramento /...

disorders-of-sex-development-clinic-320x320-2x 2

Survivorship Program

Survivorship Program

Oakland / San Francisco

Support services

Child Life

Certified child life specialists ease the stress and anxiety of childhood illness through therapeutic play, schooling and family-focused support.


Glogau Teddy Bear Rescue Fund

Families that need additional assistance during their child's hospital stay have access to toys, hotel vouchers and other amenities. Find out more.


International Services

If you're coming to UCSF from outside the U.S., we coordinate your child's appointments and provide other helpful services. Here's how to get started.


Interpreter Services & Communication Assistance

Interpreter services in many languages and TDDs are available for families that need help communicating with care teams. Here's how to access them.


Patient Relations

Patient relations reps and nursing supervisors are here to answer questions and address concerns. Learn about your rights, how to reach us and more.


School Program

Our schoolroom services and individual learning programs help children hospitalized at UCSF continue their education and get ready to return to school.


Social Services

Social workers ease the effect of illness, injury and hospitalization on your family with counseling and assistance to help you navigate the challenges.


Spiritual Care

Chaplains help UCSF patients, families and staff cope with the spiritual and emotional challenges of childhood illness. Learn more.

Clinical trials

See all clinical trials
1 in progress, 1 open to new patients
Decorative Caduceus

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma

Time to tissue collection will be used to determine the feasibility of using the results of real-time in vitro drug screening, WES and RNAseq of participant-derived specimens to guide treatment recommendations by a specialized tum...


More about this study
See all clinical trials

Our research initiatives

  • ucsf-brain-tumor-center-clinical-trials-2x

    UCSF Brain Tumor Center Clinical Trials

Awards & recognition

  • One of the nation's best in neurology & neurosurgery

  • Ranked among the nation's best in 10 specialties

Stress-free visits

Accommodations. Admissions. Procedure prep. Get the info you need for smoother hospital stays.

Prepare for your child's stay