Skip to Main Content

Brainstem glioma



Brainstem gliomas usually belong to the group of tumors known as astrocytoma, one of the most common types of brain tumor that can develop in children. Astrocytoma arises from a specific type of cell in the brain, called an astrocyte.

Brainstem gliomas are divided into subgroups based on their grade. The grade is determined by what the tumor tissue looks like under the microscope. In general, the lower a tumor's grade, the less aggressive its behavior. Brainstem gliomas can be grade 1, 2, 3 or 4 tumors.

Grade 2 astrocytomas in the brainstem frequently grow much faster than grade 2 tumors in the rest of the brain, and can transform into a higher-grade tumor. Grade 3 and grade 4 astrocytomas grow very fast, particularly in the brainstem. The reason for the very rapid growth of these tumors in this particular area of the brain is still unknown.

Because many brainstem tumors are not biopsied, a diagnosis is usually made based on the tumor's appearance on an MRI scan. Most tumors that arise from the brainstem region, other than proven grade 1 tumors, are considered highly malignant.

Contact us

To request an appointment, give us a call.

Signs & symptoms

Boys and girls are equally affected by brainstem gliomas, most often between 5 and 10 years of age. Patients usually experience sudden onset of symptoms, over a period of days or weeks.

Typical symptoms of a brainstem glioma can include:

  • Abnormalities in eye movement
  • Weakness of one side of the face
  • Numbness or weakness of the extremities
  • Difficulty with balance
  • Headaches
  • Possibly nausea


Brainstem gliomas are typically diagnosed when symptoms related to cranial nerve dysfunction — such as double vision and difficulty speaking or swallowing — lead to an imaging study. An MRI of the brain will show a mass within the brainstem. Often, the MRI is all that is needed to diagnose a brainstem glioma.

In some cases, the tumor does not have the typical appearance of most brainstem gliomas, and a neurosurgeon will discuss the option to remove the tumor surgically or, at a minimum, perform a biopsy. In recent years, brainstem lesions are biopsied much more frequently, both to confirm the diagnosis and to obtain tumor tissue for molecular analysis that may someday aid in treatment decisions.


Surgery alone can often cure grade 1 brainstem gliomas. If surgery cannot remove most of the visible tumor, radiation therapy is very effective.

Unfortunately, the majority of brainstem gliomas are rapidly growing grade 3 or grade 4 astrocytoma, and even grade 2 tumors grow quickly. Because the tumor grows directly in the brainstem, in an area called the pons, surgery to remove the tumor is not possible. This area of the brain controls many vital functions necessary for survival, including breathing, heart rate and blood pressure.

At the same time, if the tumor continues to grow, those functions can be affected by the tumor itself. For this reason, treatment is started as quickly as possible. If the treatment does not control tumor growth, problems with breathing, heart rate, blood pressure and other neurologic deficits will eventually develop.

The most effective and most common initial treatment is radiation therapy. This typically is done over a six-week period. In some cases doctors may add various forms of chemotherapy, either during or after the radiation, or both. If chemotherapy is given, it is continued for as long as it works to control tumor growth. Tumor regrowth is typically treated with chemotherapy, using either standard or experimental drugs.

In the U.S., most patients have the option to participate in a clinical research study, both for newly diagnosed brainstem glioma and for brainstem glioma that grows despite initial therapy. Most research studies include new experimental drugs.

In many cases, initial treatment will control tumor growth, often for many months. Unfortunately, these tumors tend to grow back in less than one year. Treatment for tumor regrowth is less effective than the initial treatment, and may control tumor growth for only a few months or not at all.

UCSF Benioff Children's Hospitals medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your child's doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your child's provider.

Where to get care (3)


Brain Tumor Program

Brain Tumor Program

San Francisco / Oakland


Neurosurgery Program

Neurosurgery Program

San Francisco / Oakland / Los Gatos / Greenbrae / Modesto / Sacramento /...

disorders-of-sex-development-clinic-320x320-2x 2

Survivorship Program

Survivorship Program

Oakland / San Francisco

Support services

Child Life

Certified child life specialists ease the stress and anxiety of childhood illness through therapeutic play, schooling and family-focused support.


Glogau Teddy Bear Rescue Fund

Families that need additional assistance during their child's hospital stay have access to toys, hotel vouchers and other amenities. Find out more.


International Services

If you're coming to UCSF from outside the U.S., we coordinate your child's appointments and provide other helpful services. Here's how to get started.


Interpreter Services & Communication Assistance

Interpreter services in many languages and TDDs are available for families that need help communicating with care teams. Here's how to access them.


Patient Relations

Patient relations reps and nursing supervisors are here to answer questions and address concerns. Learn about your rights, how to reach us and more.


School Program

Our schoolroom services and individual learning programs help children hospitalized at UCSF continue their education and get ready to return to school.


Social Services

Social workers ease the effect of illness, injury and hospitalization on your family with counseling and assistance to help you navigate the challenges.


Spiritual Care

Chaplains help UCSF patients, families and staff cope with the spiritual and emotional challenges of childhood illness. Learn more.

Our research initiatives

  • ucsf-brain-tumor-center-clinical-trials-2x

    UCSF Brain Tumor Center Clinical Trials

Awards & recognition

  • One of the nation's best in neurology & neurosurgery

  • Ranked among the nation's best in 10 specialties

Fetal surgery firsts

The first open fetal surgery in the world was performed at UCSF in the early 1980s.