Where I see patients (3)
Clinical trials
Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients Wit...
MTD is defined as the dose at which fewer than one-third of participants experience a dose limiting toxicity (DLT) for all participants who received at least one study intervention.
Recruiting
More about this studyBGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Glioma...
Events occurring on or after treatment on Day 1 will be classified using the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Adverse events leading to treatment discontinuation will be listed.
Recruiting
More about this studyNivolumab and DAY101 for Treatment of Craniopharyngioma in Children and Young Adults
Progression-free survival is defined as the time of documented response until disease progression as defined by Response assessment in neuro-oncology criteria (RANO) criteria. PFS will be reported by overall group at 12 months.
Recruiting
More about this studyTrametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gl...
We will employ the Bayesian optimal interval (BOIN) design to find the MTD for both continuous and intermittent dosing schedules. The BOIN design is implemented in a simple way similar to the traditional 3+3 design, but is more fl...
Recruiting
More about this studyIntra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Brain Tumors
Adverse events and clinically significant laboratory abnormalities (meeting grade 3, 4, or 5 criteria according to NCI CTCAE) will be summarized by maximum intensity and relationship to study drug(s). Grade 1 and 2 adverse events ...
Recruiting
More about this studyCombination Therapy for the Treatment of Diffuse Midline Gliomas
Percentage of participants alive and free from progression at 6 months after the initiation of the combination of the backbone (i.e., ONC201) with a novel agent given in the maintenance phase of therapy. The primary analysis for P...
Recruiting
More about this studyIndividualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma
Time to tissue collection will be used to determine the feasibility of using the results of real-time in vitro drug screening, WES and RNAseq of participant-derived specimens to guide treatment recommendations by a specialized tum...
Recruiting
More about this studyONC206 for Treatment of Newly Diagnosed, or Recurrent Diffuse Midline Gliomas, and Other Recurr...
A DLT is defined as a treatment-related adverse event (AE) or abnormal laboratory value that occurs in the first cycle of treatment (Cycle 1 for Arm A and D; Cycle 0 for Arm B and C), meets criteria for DLT as outlined below and i...
Recruiting
More about this studyA Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients ...
Safety and tolerability as assessed by the frequency and severity of dose-limiting toxicities (DLTs), AEs, laboratory and ECG tests, vital signs, weight, physical and neurological exams.
Recruiting
More about this studyA Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signa...
Recruiting
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