The pyruvate kinase test measures the level of the enzyme pyruvate kinase in the blood.
Pyruvate kinase is an
How the Test is Performed
How to Prepare for the Test
No special preparation is necessary.
If your child is having this test, it may help to explain how the test will feel and even demonstrate on a doll. Explain the reason for the test. Knowing the "how and why" may reduce your child's anxiety.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
This test is done to detect an abnormally low level of pyruvate kinase. Without enough of this enzyme, red blood cells break down faster than normal. This is called
This test helps diagnose
Results vary depending on the testing method used. In general, a normal value is 179 ± 16 units per 100 mL of red blood cells.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results.
What Abnormal Results Mean
A low level of pyruvate kinase confirms PKD.
There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Multiple punctures to locate veins
- Hematoma (blood buildup under the skin)
- Infection (a slight risk any time the skin is broken)
Elghetany MT, Schexneider KI, Banki K. Erythrocytic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 32.
Gallagher PG. Hemolytic anemias: red cell membrane and metabolic defects. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 152.
Papachristodoulou D. Energy metabolism. In: Naish J, Syndercombe Court D, eds. Medical Sciences. 3rd ed. Philadelphia, PA: Elsevier; 2019:chap 3.
van Solinge WW, van Wijk R. Enzymes of the red blood cell. In: Rifai N, ed. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Philadelphia, PA: Elsevier; 2018:chap 30.
Review Date: 06/02/2020
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright ©2019 A.D.A.M., Inc., as modified by University of California San Francisco. Any duplication or distribution of the information contained herein is strictly prohibited.
Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Please discuss with your doctor any questions or concerns you may have.