The osmolality urine test measures the concentration of chemicals in urine.
Osmolality can also be measured using a
How the Test is Performed
How to Prepare for the Test
Your provider may tell you that you need to limit your fluid intake 12 to 14 hours before the test.
Your provider will ask you to temporarily stop taking any medicines that may affect the test results. Be sure to tell your provider about all the medicines you take, including dextran and sucrose. DO NOT stop taking any medicine before talking to your provider.
Other things can also affect the test results. Tell your provider if you recently:
- Had any type of anesthesia for an operation.
- Received intravenous dye (contrast medium) for an imaging test such as a CT or MRI scan.
- Used herbs or natural remedies, especially Chinese herbs.
How the Test will Feel
The test involves normal urination. There is no discomfort.
Why the Test is Performed
This test helps check your body's water balance and urine concentration.
Osmolality is a more exact measurement of urine concentration than the
Normal values are as follows:
- Random specimen: 50 to 1200 mOsm/kg (50 to 1200 mmol/kg)
- 12 to 14 hour fluid restriction: Greater than 850 mOsm/kg (850 mmol/kg)
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
What Abnormal Results Mean
Abnormal results are indicated as follows:
Higher than normal measurements may indicate:
- Adrenal glands do not produce enough hormones (
Addison diseaseor other types of adrenal insufficiency)
- Glucose (a type of sugar) in the urine
- High sodium level in the blood
- Loss of body fluids (dehydration)
- Narrowing of the kidney artery (renal artery stenosis)
- Syndrome of inappropriate ADH secretion (
Lower than normal measurements may indicate:
- Damage to kidney tubule cells (
renal tubular necrosis) Diabetes insipidus
- Drinking too much fluid
- Kidney failure
- Low sodium level in the blood
- Severe kidney infection (pyelonephritis)
There are no risks with this test.
Berl T, Sands JM. Disorders of water metabolism. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 8.
Oh MS, Briefel G, Pincus MR. Evaluation of renal function, water, electrolytes, and acid-base balance. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 15.
Review Date: 21/07/2021
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