Urine immunoelectrophoresis is a lab test that measures immunoglobulins in a urine sample.
Immunoglobulins are proteins that function as
Immunoglobulins can also be measured in the
Immunoglobulin electrophoresis - urine; Gamma globulin electrophoresis - urine; Urine immunoglobulin electrophoresis; IEP - urine
How the Test is Performed
After you provide a urine sample, it is sent to the laboratory. There, the laboratory specialist will place the urine sample on special paper and apply an electric current. The various proteins move and form visible bands, which reveal the general amounts of each protein.
How to Prepare for the Test
Your provider may ask you to collect the first morning urine, which is the most concentrated.
If you are taking the collection from an infant, you may need extra collection bags.
How the Test will Feel
The test involves only normal urination, and there is no discomfort.
Why the Test is Performed
This test is used to measure the amounts of various immunoglobulins in urine. Most often, it is done after a large amount of protein is found in the urine.
Normally there is no protein, or only a small amount of protein in the urine. When there is protein in the urine, it normally consists of mainly albumin.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean
Immunoglobulin in the urine can result from:
- An abnormal buildup of proteins in tissues and organs (
- Blood cancer called
- Kidney disorders such as
IgA nephropathyor IgM nephropathy
Some people have monoclonal immunoglobulins, but do not have cancer. This is called monoclonal gammopathy of unknown significance, or MGUS.
Chernecky CC, Berger BJ. Protein electrophoresis – urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:920-923.
McPherson RA. Specific proteins. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. Philadelphia, PA: Elsevier; 2017:chap 19.
Review Date: 02/04/2018
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