A histocompatibility antigen blood test looks at proteins called human leukocyte antigens (HLAs). These are found on the surface of almost all cells in the human body. HLAs are found in large amounts on the surface of white blood cells. They help the immune system tell the difference between body tissue and substances that are not from your own body.
HLA typing; Tissue typing
How the Test is Performed
How to Prepare for the Test
You do not need to prepare for this test.
Why the Test is Performed
The results from this test can be used to identify good matches for tissue grafts and organ transplants. These may include
It may also be used to:
- Diagnose certain autoimmune disorders. Drug-induced hypersensitivity is an example.
- Determine relationships between children and parents when such relationships are in question.
- Monitor treatment with some medicines.
You have a small set of HLAs that are passed down from your parents. Children, on average, will have half of their HLAs match half of their mother's and half of their HLAs match half of their father's.
It is unlikely that two unrelated people will have the same HLA makeup. However, identical twins may match each other.
Some HLA types are more common in certain
There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Fainting or feeling lightheaded
- Multiple punctures to locate veins
- Hematoma (blood buildup under the skin)
- Excessive bleeding
- Infection (a slight risk any time the skin is broken)
Bray R, Sullivan C, Krummey S, Gebel HM. Human leukocyte antigen: the major histocompatibility complex of humans. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 50.
Monos DS, Rajalingam R. The major histocompatibility complex. In: Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck JM, eds. Clinical Immunology: Principles and Practice. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 5.
Wang E, Adams S, Stroncek DF, Marincola FM. Human leukocyte antigen and human neutrophil antigen systems. In: Hoffman R, Benz EJ, Silberstein LE et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 114.
Review Date: 24/01/2023
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