The fetal-maternal erythrocyte distribution test is used to measure the number of the unborn baby's red blood cells in a pregnant woman's blood.
Kleihauer-Betke stain; Flow cytometry - fetal-maternal erythrocyte distribution; Rh incompatibility - erythrocyte distribution
How the Test is Performed
How to Prepare for the Test
No special preparation is necessary for this test.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
If the baby's blood is Rh+ and gets into the mother's Rh- bloodstream, her body will produce antibodies. These antibodies could pass back through the placenta and harm the developing baby's red blood cells. This can cause mild to serious
This test determines the amount of blood that has been exchanged between the mother and fetus. All Rh- pregnant women should get this test if they have bleeding or a risk of bleeding during the pregnancy.
In a woman whose blood is Rh incompatible with her infant, this test helps find out how much Rh immune globulin (RhoGAM) she must receive to prevent her body from producing abnormal proteins that attack the unborn baby in future pregnancies.
In a normal value, no or few of the baby's cells are in the mother's blood. The standard dose of Rh immune globulin is enough in this case.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean
In an abnormal test result, blood from the unborn baby is leaking into the mother's blood circulation. The more of the baby's cells there are, the more Rh immune globulin the mother must receive.
There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Multiple punctures to locate veins
- Fainting or feeling lightheaded
Hematoma(blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Chernecky CC, Berger BJ. Betke-Kleihauer stain (fetal hemoglobin stain, Kleihauer-Betke stain, K-B) - diagnostic. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:193-194.
Cooling L, Downs T. Immunohematology. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 36.
Moise KJ. Red cell alloimmunization. In: Landon MB, Galan HL, Jauniaux ERM, et al, eds. Gabbe's Obstetrics: Normal and Problem Pregnancies. 8th ed. Philadelphia, PA: Elsevier; 2021:chap 40.
Review Date: 03/07/2022
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