Sanjeev Datar, MD, PhD

Pediatric critical care specialist

Dr. Sanjeev Datar is a critical care specialist who cares for children in the intensive care units, including cardiac intensive care.

Datar's research, which is funded by the National Institutes of Health, is focused on better understanding how the lymphatic vasculature works in health and disease. Specifically, he is studying new ways to support and improve lymphatic function in the lungs of patients with congenital heart disease.

Datar earned his medical degree at the University of Washington and a doctorate in molecular and cellular biology in UW's joint program with Fred Hutchinson Cancer Research Center. He completed a residency in pediatrics and a fellowship in pediatric critical care medicine at UCSF, joining the faculty in 2008.

Datar has received a variety of honors, including the 2007 Charlotte Rose Coleman – Fry Award for pediatric critical care fellows, an Excellence in Teaching Award in 2012 from the UCSF Haile T. Debas Academy of Medical Educators, a Beginning Grant-in-Aid Award in 2012 from the American Heart Association and most recently the Ida M. Cannon for integrity from the Society for Social Work Leadership in Health Care.

Datar is a member of the Society for Pediatric Research, Pulmonary Vascular Research Institute and Lymphatic Education & Research Network.

Clinics

Pediatric Cardiac Intensive Care Unit
1975 Fourth St., Fourth Floor
San Francisco, CA 94158
Phone: (415) 353-1955
Fax: (415) 353-9144

Pediatric Intensive Care Unit
1975 Fourth St., Fourth Floor
San Francisco, CA 94158
Phone: (415) 353-1352

More about Sanjeev Datar

Additional Languages

Marathi

Education

UW School of Medicine 2001

Residencies

UCSF, Pediatrics 2004

Fellowships

UCSF, Pediatric Critical Care Medicine 2008

Selected Research and Publications

  1. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme J, Hata A, Fineman JR. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. Am J Physiol Heart Circ Physiol. 2018 Jun 15.
  2. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. KLF2-mediated Disruption of PPAR? Signaling in Lymphatic Endothelial Cells Exposed to Chronically Increased Pulmonary Lymph Flow. Am J Physiol Heart Circ Physiol. 2018 Apr 06.
  3. Burke E, Datar SA. Lymphatic dysfunction in critical illness. Curr Opin Pediatr. 2018 Mar 13.
  4. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatr Crit Care Med. 2017 Oct; 18(10):931-934.
  5. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 Oct 01; 311(4):H944-H957.
  6. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2016 Jul 01; 311(1):H137-45.
  7. Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Am J Physiol Heart Circ Physiol. 2015 Jul 01; 309(1):H157-65.
  8. Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. J Cell Physiol. 2014 Nov; 229(11):1802-16.
  9. Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. Am J Physiol Heart Circ Physiol. 2014 Apr 15; 306(8):H1222-30.
  10. Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2014 Apr 01; 306(7):H954-62.
  11. Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). J Thorac Cardiovasc Surg. 2014 Jul; 148(1):212-9.
  12. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatr Res. 2013 Jul; 74(1):39-47.
  13. Radman M, Mack R, Barnoya J, CastaƱeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50.
  14. Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. J Cell Biochem. 2013 Feb; 114(2):435-447.
  15. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM. Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb. Pulm Pharmacol Ther. 2013 Apr; 26(2):271-80.
  16. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatr Res. 2013 Jan; 73(1):54-61.
  17. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5.
  18. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM. PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PLoS One. 2012; 7(9):e41555.
  19. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. J Thorac Cardiovasc Surg. 2013 May; 145(5):1279-87.
  20. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatr Cardiol. 2013 Jun; 34(5):1254-7.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.