Ophir Klein, MD, PhD

Chair, Division of Craniofacial Anomalies
Chief, Division of Medical Genetics
Pediatric medical geneticist

Dr. Ophir Klein is a specialist in pediatric medical genetics who cares for children with skull, face and dental abnormalities, which may be part of a genetic syndrome, as well as general genetic disorders. His research interests include craniofacial and tooth developmental biology and adult stem cell biology.

Klein completed his medical degree, doctorate and residency in pediatrics at Yale University. He completed a residency in medical genetics and a fellowship in developmental biology at UCSF. He is a member of the American Academy of Pediatrics, American Society of Human Genetics, American College of Medical Genetics, International Association for Dental Research, American Association for Dental Research, American Cleft Palate – Craniofacial Association, American Society for Bone and Mineral Research, and Society for Pediatric Research.

Clinics

Craniofacial Center
1825 Fourth St., Fifth Floor, 5C
San Francisco, CA 94158
Phone: (415) 476-2271
Fax: (415) 476-9513

Disorders of Sex
Development Clinic

1825 Fourth St., Fifth Floor, 5B
San Francisco, CA 94158
Phone: (415) 353-2200
Fax: (415) 353-2480

Conditions & Treatments

More about Ophir Klein

Education

Yale School of Medicine, MD 2000

Residencies

Yale University, Pediatrics 2003
UCSF, Genetics 2007

Fellowships

UCSF, Developmental Biology 2007

Selected Research and Publications

  1. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 Jul 17; 9(1):2854.
  2. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 Jul 16.
  3. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor. Cell Stem Cell. 2018 Jul 05; 23(1):147.
  4. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 Jun 27.
  5. Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. SOX2 Regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 Jun 26.
  6. Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, Pogontke C, Carmona RM, Salvador JM, Perez-Pomares JM, Klein OD, Prósper F, Jimenez-Borreguero LJ, Bernad A. Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2018 Jun 21.
  7. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 Jun 13; 7.
  8. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 Jun 13; 9(1):2333.
  9. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 Jan 23; 22(4):1003-1015.
  10. Kalha S, Shrestha B, Sanz Navarro M, Jones KB, Klein OD, Michon F. Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing. Stem Cells. 2018 Apr; 36(4):562-573.
  11. Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F. Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor. Development. 2018 01 08; 145(1).
  12. Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD. Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a. Hum Mol Genet. 2018 Jan 01; 27(1):107-119.
  13. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 Jan 22; 44(2):165-178.e6.
  14. Larson JR, Manyama MF, Cole JB, Gonzalez PN, Percival CJ, Liberton DK, Ferrara TM, Riccardi SL, Kimwaga EA, Mathayo J, Spitzmacher JA, Rolian C, Jamniczky HA, Weinberg SM, Roseman CC, Klein O, Lukowiak K, Spritz RA, Hallgrimsson B. Body size and allometric variation in facial shape in children. Am J Phys Anthropol. 2018 02; 165(2):327-342.
  15. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP. Meeting report: a hard look at the state of enamel research. Int J Oral Sci. 2017 Nov 22; 9(11):e3.
  16. Neben CL, Lo M, Jura N, Klein OD. Feedback regulation of RTK signaling in development. Dev Biol. 2017 Oct 26.
  17. Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD. Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Nov; 32(11):2219-2231.
  18. Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC. IRF6 and SPRY4 Signaling Interact in Periderm Development. J Dent Res. 2017 Oct; 96(11):1306-1313.
  19. Du W, Hu JK, Du W, Klein OD. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017 09 08; 292(36):15062-15069.
  20. El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul; 13(7):e1006914.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.