A. James Barkovich, MD

Chief of Pediatric Neuroradiology

Dr. A. James Barkovich is chief of pediatric neuroradiology at UCSF Benioff Children's Hospital. He specializes in diagnosing and treating neurological disorders in infants and children using state-of-the-art imaging technologies.

Barkovich's research focuses on brain disorders. His work includes correlating genetic defects with findings from brain imaging to facilitate diagnosis, early detection of brain injury in newborns with encephalopathy, and early detection of brain injury in premature newborns and its correlation with neurological development.

Barkovich earned his medical degree at the George Washington University and completed a residency in radiology at Letterman Army Medical Center and a fellowship in neuroradiology at Walter Reed National Military Medical Center. He served as chief of neuroradiology and special procedures at Letterman Army Medical Center until 1989, when he joined UCSF.

Barkovich is past president of the American Society of Pediatric Neuroradiology and former secretary and president of the American Society of Neuroradiology. He has received many research awards and is the author of several textbooks, including Pediatric Neuroimaging, the definitive textbook of pediatric neuroradiology.

Clinics

Neuro-Intensive Care Nursery
1975 Fourth St., Third Floor
San Francisco, CA 94158
Phone: (415) 353-1565
Fax: (415) 353-1202

Radiology
1975 Fourth St., First Floor
San Francisco, CA 94158
Appointments: (415) 353-2573
Office: (415) 476-1568

More about A. James Barkovich

Additional Languages

French

Education

George Washington University School of Medicine and Health Sciences 1980

Residencies

Letterman Army Medical Center, Radiology 1984

Fellowships

Walter Reed National Military Medical Center, Neuroradiology 1986

Selected Research and Publications

  1. Barkovich AJ, Deon S. Reprint of "Hypomyelinating disorders: An MRI approach. Neurobiol Dis. 2016 08; 92(Pt A):46-54.
  2. Barkovich AJ, Deon S. Hypomyelinating disorders: An MRI approach. Neurobiol Dis. 2016 Mar; 87:50-8.
  3. Al-Maawali A, Barry BJ, Rajab A, El-Quessny M, Seman A, Coury SN, Barkovich AJ, Yang E, Walsh CA, Mochida GH, Stoler JM. Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures. Am J Med Genet A. 2016 Feb; 170A(2):435-40.
  4. Fullerton HJ, Hills NK, Elkind MS, Dowling MM, Wintermark M, Glaser CA, Tan M, Rivkin MJ, Titomanlio L, Barkovich AJ, deVeber GA. Infection, vaccination, and childhood arterial ischemic stroke: Results of the VIPS study. Neurology. 2015 Oct 27; 85(17):1459-66.
  5. Takanashi J, Mizuguchi M, Terai M, Barkovich AJ. Disrupted glutamate-glutamine cycle in acute encephalopathy with biphasic seizures and late reduced diffusion. Neuroradiology. 2015 Nov; 57(11):1163-8.
  6. Tunovic S, Barañano KW, Barkovich JA, Strober JB, Jamal L, Slavotinek AM. Novel KIF7 missense substitutions in two patients presenting with multiple malformations and features of acrocallosal syndrome. Am J Med Genet A. 2015 Nov; 167A(11):2767-76.
  7. Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TT, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJF, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJP, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF. An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol. 2015 Aug; 17(8):1074-1087.
  8. Gano D, Andersen SK, Glass HC, Rogers EE, Glidden DV, Barkovich AJ, Ferriero DM. Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age. Pediatr Res. 2015 Sep; 78(3):323-9.
  9. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale RD, Barkovich AJ, Sherr EH. De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy. Ann Clin Transl Neurol. 2015 Jun; 2(6):623-35.
  10. Barkovich AJ, Dobyns WB, Guerrini R. Malformations of cortical development and epilepsy. Cold Spring Harb Perspect Med. 2015 May 01; 5(5):a022392.
  11. Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan WH, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH. Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Am J Hum Genet. 2015 May 07; 96(5):709-19.
  12. D'Gama AM, Geng Y, Couto JA, Martin B, Boyle EA, LaCoursiere CM, Hossain A, Hatem NE, Barry BJ, Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J, Mathern GW, Walsh CA, Poduri A. Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia. Ann Neurol. 2015 Apr; 77(4):720-5.
  13. Vulto-van Silfhout AT, Nakagawa T, Bahi-Buisson N, Haas SA, Hu H, Bienek M, Vissers LE, Gilissen C, Tzschach A, Busche A, Müsebeck J, Rump P, Mathijssen IB, Avela K, Somer M, Doagu F, Philips AK, Rauch A, Baumer A, Voesenek K, Poirier K, Vigneron J, Amram D, Odent S, Nawara M, Obersztyn E, Lenart J, Charzewska A, Lebrun N, Fischer U, Nillesen WM, Yntema HG, Järvelä I, Ropers HH, de Vries BB, Brunner HG, van Bokhoven H, Raymond FL, Willemsen MA, Chelly J, Xiong Y, Barkovich AJ, Kalscheuer VM, Kleefstra T, de Brouwer AP. Variants in CUL4B are associated with cerebral malformations. Hum Mutat. 2015 Jan; 36(1):106-17.
  14. Tate MC, Lindquist RA, Nguyen T, Sanai N, Barkovich AJ, Huang EJ, Rowitch DH, Alvarez-Buylla A. Postnatal growth of the human pons: a morphometric and immunohistochemical analysis. J Comp Neurol. 2015 Feb 15; 523(3):449-62.
  15. Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014 Dec; 45(12):3597-605.
  16. Jissendi-Tchofo P, Severino M, Nguema-Edzang B, Toure C, Soto Ares G, Barkovich AJ. Update on neuroimaging phenotypes of mid-hindbrain malformations. Neuroradiology. 2015 Feb; 57(2):113-38.
  17. Kanal E, Froelich J, Barkovich AJ, Borgstede J, Bradley W, Gimbel JR, Gosbee J, Greenberg T, Jackson E, Larson P, Lester J, Sebek E, Shellock FG, Weinreb J, Wilkoff BL, Hernandez D. Standardized MR terminology and reporting of implants and devices as recommended by the American College of Radiology Subcommittee on MR Safety. Radiology. 2015 Mar; 274(3):866-70.
  18. Gano D, Andersen SK, Partridge JC, Bonifacio SL, Xu D, Glidden DV, Ferriero DM, Barkovich AJ, Glass HC. Diminished white matter injury over time in a cohort of premature newborns. J Pediatr. 2015 Jan; 166(1):39-43.
  19. Wang DD, Benkli B, Auguste KI, Garcia PA, Sullivan J, Barkovich AJ, Chang EF, Tihan T. Unilateral holohemispheric central nervous system lesions associated with medically refractory epilepsy in the pediatric population: a retrospective series of hemimegalencephaly and Rasmussen's encephalitis. J Neurosurg Pediatr. 2014 Dec; 14(6):573-84.
  20. De Ciantis A, Barkovich AJ, Cosottini M, Barba C, Montanaro D, Costagli M, Tosetti M, Biagi L, Dobyns WB, Guerrini R. Ultra-high-field MR imaging in polymicrogyria and epilepsy. AJNR Am J Neuroradiol. 2015 Feb; 36(2):309-16.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.