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A. James Barkovich, M.D.

Chief of Pediatric Neuroradiology

Dr. A. James Barkovich is chief of Pediatric Neuroradiology at UCSF Benioff Children's Hospital, where he specializes in high resolution, state-of-the-art anatomic and functional imaging to diagnose and treat neurological disorders in infants and children. In his research, he studies brain disorders including correlating genetic defects with brain imaging findings to facilitate diagnosis, early detection of brain injury in newborns with encephalopathy, and early detection and correlation with neurodevelopmental outcome of brain injury in premature newborns.

Barkovich earned a medical degree at George Washington University in Washington, D.C. and completed a residency in radiology at Letterman Army Medical Center and a fellowship in neuroradiolgy at the Walter Reed Army Medical Center. He served as chief of neuroradiology and special procedures at Letterman Army Medical Center in San Francisco until 1989 when he joined UCSF. He is past president of the American Society of Pediatric Neuroradiology and former secretary and president of the American Society of Neuroradiology. He has received many research awards and is the author of several textbooks, including Pediatric Neuroimaging, the definitive textbook of pediatric neuroradiology.

Clinics

Neuro-Intensive Care Nursery
505 Parnassus Ave., 15th floor
San Francisco, CA 94143
Phone: (415) 353-1565

More about A. James Barkovich

Additional Languages

French

Education

George Washington University School of Medicine 1980

Residencies

Letterman Army Medical Center, Radiology 1984

Fellowships

Walter Reed Army Hospital, Neuroradiology 1986

Selected Research and Publications

  1. Tymofiyeva O, Ziv E, Barkovich AJ, Hess CP, Xu D. Brain without Anatomy: Construction and Comparison of Fully Network-Driven Structural MRI Connectomes. PLoS One. 2014; 9(5):e96196.
  2. Jenster M, Bonifacio SL, Ruel T, Rogers EE, Tam EW, Partridge JC, Barkovich AJ, Ferriero DM, Glass HC. Maternal or neonatal infection: association with neonatal encephalopathy outcomes. Pediatr Res. 2014 Jul; 76(1):93-9.
  3. Mirzaa GM, Millen KJ, Barkovich AJ, Dobyns WB, Paciorkowski AR. The Developmental Brain Disorders Database (DBDB): A curated neurogenetics knowledge base with clinical and research applications. Am J Med Genet A. 2014 Jun; 164(6):1503-11.
  4. Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Sestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA. Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning. Science. 2014 Feb 14; 343(6172):764-8.
  5. Poduri A, Heinzen EL, Chitsazzadeh V, Lasorsa FM, Elhosary PC, LaCoursiere CM, Martin E, Yuskaitis CJ, Hill RS, Atabay KD, Barry B, Partlow JN, Bashiri FA, Zeidan RM, Elmalik SA, Kabiraj MM, Kothare S, Stödberg T, McTague A, Kurian MA, Scheffer IE, Barkovich AJ, Palmieri F, Salih MA, Walsh CA. SLC25A22 is a novel gene for migrating partial seizures in infancy. Ann Neurol. 2013 Dec; 74(6):873-82.
  6. Ziv E, Tymofiyeva O, Ferriero DM, Barkovich AJ, Hess CP, Xu D. A machine learning approach to automated structural network analysis: application to neonatal encephalopathy. PLoS One. 2013; 8(11):e78824.
  7. Takanashi J, Nitta N, Iwasaki N, Saito S, Tanaka R, Barkovich AJ, Aoki I. Neurochemistry in shiverer mouse depicted on MR spectroscopy. J Magn Reson Imaging. 2014 Jun; 39(6):1550-7.
  8. Sajan SA, Fernandez L, Nieh SE, Rider E, Bukshpun P, Wakahiro M, Christian SL, Rivière JB, Sullivan CT, Sudi J, Herriges MJ, Paciorkowski AR, Barkovich AJ, Glessner JT, Millen KJ, Hakonarson H, Dobyns WB, Sherr EH. Both rare and de novo copy number variants are prevalent in agenesis of the corpus callosum but not in cerebellar hypoplasia or polymicrogyria. PLoS Genet. 2013; 9(10):e1003823.
  9. Hills LB, Masri A, Konno K, Kakegawa W, Lam AT, Lim-Melia E, Chandy N, Hill RS, Partlow JN, Al-Saffar M, Nasir R, Stoler JM, Barkovich AJ, Watanabe M, Yuzaki M, Mochida GH. Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans. Neurology. 2013 Oct 15; 81(16):1378-86.
  10. Shiba N, Daza RA, Shaffer LG, Barkovich AJ, Dobyns WB, Hevner RF. Neuropathology of brain and spinal malformations in a case of monosomy 1p36. Acta Neuropathol Commun. 2013; 1(1):45.
  11. Curry CJ, Rosenfeld JA, Grant E, Gripp KW, Anderson C, Aylsworth AS, Saad TB, Chizhikov VV, Dybose G, Fagerberg C, Falco M, Fels C, Fichera M, Graakjaer J, Greco D, Hair J, Hopkins E, Huggins M, Ladda R, Li C, Moeschler J, Nowaczyk MJ, Ozmore JR, Reitano S, Romano C, Roos L, Schnur RE, Sell S, Suwannarat P, Svaneby D, Szybowska M, Tarnopolsky M, Tervo R, Tsai AC, Tucker M, Vallee S, Wheeler FC, Zand DJ, Barkovich AJ, Aradhya S, Shaffer LG, Dobyns WB. The duplication 17p13.3 phenotype: analysis of 21 families delineates developmental, behavioral and brain abnormalities, and rare variant phenotypes. Am J Med Genet A. 2013 Aug; 161A(8):1833-52.
  12. Dimitropoulos A, McQuillen PS, Sethi V, Moosa A, Chau V, Xu D, Brant R, Azakie A, Campbell A, Barkovich AJ, Poskitt KJ, Miller SP. Brain injury and development in newborns with critical congenital heart disease. Neurology. 2013 Jul 16; 81(3):241-8.
  13. Tymofiyeva O, Hess CP, Ziv E, Lee PN, Glass HC, Ferriero DM, Barkovich AJ, Xu D. A DTI-based template-free cortical connectome study of brain maturation. PLoS One. 2013; 8(5):e63310.
  14. Doherty D, Millen KJ, Barkovich AJ. Midbrain and hindbrain malformations: advances in clinical diagnosis, imaging, and genetics. Lancet Neurol. 2013 Apr; 12(4):381-93.
  15. Wickremasinghe AC, Rogers EE, Johnson BC, Shen A, Barkovich AJ, Marco EJ. Children born prematurely have atypical sensory profiles. J Perinatol. 2013 Aug; 33(8):631-5.
  16. Sethi V, Tabbutt S, Dimitropoulos A, Harris KC, Chau V, Poskitt K, Campbell A, Azakie A, Xu D, Barkovich AJ, Miller SP, McQuillen PS. Single-ventricle anatomy predicts delayed microstructural brain development. Pediatr Res. 2013 May; 73(5):661-7.
  17. Barkovich J. Complication begets clarification in classification. Brain. 2013 Feb; 136(Pt 2):368-73.
  18. ACR guidance document on MR safe practices: 2013. J Magn Reson Imaging. 2013 Mar; 37(3):501-30.
  19. Xu D, Mukherjee P, Barkovich AJ. Pediatric brain injury: can DTI scalars predict functional outcome? Pediatr Radiol. 2013 Jan; 43(1):55-9.
  20. Dies KA, Bodell A, Hisama FM, Guo CY, Barry B, Chang BS, Barkovich AJ, Walsh CA. Schizencephaly: association with young maternal age, alcohol use, and lack of prenatal care. J Child Neurol. 2013 Feb; 28(2):198-203.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.