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NF/Ras Pathway Clinic

The NF/Ras Pathway Clinic's approach to genetic medicine continues to evolve. Recently, we learned that a significant overlap exists in the medical and health issues of individuals with certain genetic conditions that have in some way interacted with an important cell signaling pathway called the RAS/MAPK pathway.

Our clinic provides health care support and management for children who have, or at risk for having a Ras pathway disorder. These include:

  • Capillary malformation-arteriovenous malformation syndrome (RASA1)
  • Cardio-facio-cutaneous syndrome
  • Costello syndrome
  • Legius syndrome
  • LEOPARD syndrome
  • Noonan syndrome
  • Neurofibromatosis type 1
  • Neurofibromatosis type 2
  • Schwannomatosis
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The NF/Ras Pathway Clinic offers patients comprehensive case management along with referrals to a network of more than 50 specialists.

The goal of the clinic is to help individuals and families by:

  • Working with primary care providers to ensure that they have the information they want to properly care for patients with Ras pathway disorders.
  • Providing genetic counseling as part of every consultation to allow for on-going education regarding the condition and any new treatments or clinical trial opportunities.
  • Helping individuals and families get in contact with others who have the same condition.
  • Providing seamless transitions from pediatric to adult care specialists, and serving as the ongoing consultants for continuity of care.
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Request an Appointment

You'll need a referral from your child's pediatrician or specialist to make an appointment. Once you have the referral, please call the number below.

Getting Here

NF/Ras Pathway Clinic
400 Parnassus, Second Floor
San Francisco, CA 94143
Phone: (415) 476-2757
Fax: (415) 476-9305

What to Bring

    • Health insurance information including authorizations or referrals
    • List of prescription medications and dosages
    • List of medications that you're allergic to
    • List of questions you may have
    • Recent test results related to your condition
    • Paper and pencil to take notes
    • Snacks, toys or books to keep your child entertained, as visits may last up to two hours

Research and Clinical Trials

Last updated July 14, 2010

During your child's first visit, you and your child will meet with a team of experts, including a genetic counselor, medical geneticist and a medical genetics fellow. Our team will take the time to understand your child's current symptoms, past medical history and family history. This will be followed by a thorough physical examination, in which we take a careful look at your child from head to toe. Finally, we will meet together to discuss and explain our thoughts and make recommendations for your child.

Occasionally, testing or a referral to a specialist may be recommended to help with diagnosis or management. Blood work and X-rays can occasionally be performed on the day of the visit if your insurance plan does not require prior authorization. However, other tests and referrals to specialists will need to be scheduled for a different day. None of the blood tests that we would recommend during your child's initial visit require you to be fasting, so your child is welcome to eat and drink as he or she normally does prior to the appointment.