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A. James Barkovich, M.D.

Chief of Pediatric Neuroradiology

Dr. A. James Barkovich is chief of Pediatric Neuroradiology at UCSF Benioff Children's Hospital, where he specializes in high resolution, state-of-the-art imaging to diagnose and treat neurological disorders in infants and children. In his research, he studies brain disorders including correlating genetic defects with brain imaging findings to facilitate diagnosis, early detection of brain injury in newborns with encephalopathy, and early detection and correlation with neurodevelopmental outcome of brain injury in premature newborns.

Barkovich earned a medical degree at George Washington University in Washington, D.C. and completed a residency in radiology at Letterman Army Medical Center and a fellowship in neuroradiolgy at the Walter Reed Army Medical Center. He served as chief of neuroradiology and special procedures at Letterman Army Medical Center in San Francisco until 1989 when he joined UCSF. He is past president of the American Society of Pediatric Neuroradiology and former secretary and president of the American Society of Neuroradiology. He has received many research awards and is the author of several textbooks, including Pediatric Neuroimaging, the definitive textbook of pediatric neuroradiology.

Clinics

Neuro-Intensive Care Nursery
505 Parnassus Ave., 15th floor
San Francisco, CA 94143
Phone: (415) 353-1565

More about A. James Barkovich

Additional Languages

French

Education

George Washington University School of Medicine 1980

Residencies

Letterman Army Medical Center, Radiology 1984

Fellowships

Walter Reed Army Hospital, Neuroradiology 1986

Selected Research and Publications

  1. Tymofiyeva O, Hess CP, Ziv E, Lee PN, Glass HC, Ferriero DM, Barkovich AJ, Xu D. A DTI-Based Template-Free Cortical Connectome Study of Brain Maturation. PLoS One. 2013; 8(5):e63310.
  2. Doherty D, Millen KJ, Barkovich AJ. Midbrain and hindbrain malformations: advances in clinical diagnosis, imaging, and genetics. Lancet Neurol. 2013 Apr; 12(4):381-93.
  3. Sethi V, Tabbutt S, Dimitropoulos A, Harris KC, Chau V, Poskitt K, Campbell A, Azakie A, Xu D, Barkovich AJ, Miller SP, McQuillen PS. Single ventricle anatomy predicts delayed microstructural brain development. Pediatr Res. 2013 Feb 13.
  4. Barkovich J. Complication begets clarification in classification. Brain. 2013 Feb; 136(Pt 2):368-73.
  5. ACR guidance document on MR safe practices: 2013. J Magn Reson Imaging. 2013 Mar; 37(3):501-30.
  6. Xu D, Mukherjee P, Barkovich AJ. Pediatric brain injury: can DTI scalars predict functional outcome? Pediatr Radiol. 2013 Jan; 43(1):55-9.
  7. Dies KA, Bodell A, Hisama FM, Guo CY, Barry B, Chang BS, Barkovich AJ, Walsh CA. Schizencephaly: association with young maternal age, alcohol use, and lack of prenatal care. J Child Neurol. 2013 Feb; 28(2):198-203.
  8. Aldinger KA, Kogan J, Kimonis V, Fernandez B, Horn D, Klopocki E, Chung B, Toutain A, Weksberg R, Millen KJ, Barkovich AJ, Dobyns WB. Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion. Am J Med Genet A. 2013 Jan; 161(1):131-6.
  9. Wang DD, Deans AE, Barkovich AJ, Tihan T, Barbaro NM, Garcia PA, Chang EF. Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control. J Neurosurg. 2013 Feb; 118(2):337-44.
  10. Takanashi J, Okamoto N, Yamamoto Y, Hayashi S, Arai H, Takahashi Y, Maruyama K, Mizuno S, Shimakawa S, Ono H, Oyanagi R, Kubo S, Barkovich AJ, Inazawa J. Clinical and radiological features of Japanese patients with a severe phenotype due to CASK mutations. Am J Med Genet A. 2012 Dec; 158A(12):3112-8.
  11. González G, Vedolin L, Barry B, Poduri A, Walsh C, Barkovich AJ. Location of periventricular nodular heterotopia is related to the malformation phenotype on MRI. AJNR Am J Neuroradiol. 2013 Apr; 34(4):877-83.
  12. Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10; 4(155):155ra137.
  13. Burger IM, Filly RA, Bowie J, Barkovich AJ. The grand unifying theory of bright echoes in the fetal and neonatal brain. J Ultrasound Med. 2012 Oct; 31(10):1665-73.
  14. Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012 Nov; 44(11):1260-4.
  15. Scott JA, Hamzelou KS, Rajagopalan V, Habas PA, Kim K, Barkovich AJ, Glenn OA, Studholme C. 3D morphometric analysis of human fetal cerebellar development. Cerebellum. 2012 Sep; 11(3):761-70.
  16. Pisano T, Barkovich AJ, Leventer RJ, Squier W, Scheffer IE, Parrini E, Blaser S, Marini C, Robertson S, Tortorella G, Rosenow F, Thomas P, McGillivray G, Andermann E, Andermann F, Berkovic SF, Dobyns WB, Guerrini R. Peritrigonal and temporo-occipital heterotopia with corpus callosum and cerebellar dysgenesis. Neurology. 2012 Sep 18; 79(12):1244-51.
  17. Hinkley LB, Marco EJ, Findlay AM, Honma S, Jeremy RJ, Strominger Z, Bukshpun P, Wakahiro M, Brown WS, Paul LK, Barkovich AJ, Mukherjee P, Nagarajan SS, Sherr EH. The role of corpus callosum development in functional connectivity and cognitive processing. PLoS One. 2012; 7(8):e39804.
  18. Zaki MS, Saleem SN, Dobyns WB, Barkovich AJ, Bartsch H, Dale AM, Ashtari M, Akizu N, Gleeson JG, Grijalvo-Perez AM. Diencephalic-mesencephalic junction dysplasia: a novel recessive brain malformation. Brain. 2012 Aug; 135(Pt 8):2416-27.
  19. Tangtiphaiboontana J, Hess CP, Bayer M, Drolet BA, Nassif LM, Metry DW, Barkovich AJ, Frieden IJ, Fullerton HJ. Neurodevelopmental Abnormalities in Children With PHACE Syndrome. J Child Neurol. 2013 May; 28(5):608-14.
  20. Bonifacio SL, Saporta A, Glass HC, Lee P, Glidden DV, Ferriero DM, Barkovich AJ, Xu D. Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei. AJNR Am J Neuroradiol. 2012 Dec; 33(11):2050-5.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions by logging on to UCSF Profiles.